The scrolling direction on the mouse set to "natural" should not dictate how zooming in XD operates. Zooming in XD should either be linked to the operating system parameter and then switchable in-app or have its own setting in-app that does not read the setting in system preferences. The setting in System Preferences > Mouse > Point & Click > Scroll direction, makes sense when scrolling content vertically and does not relate intuitively to zooming content.
The scrolling direction on the mouse set to "natural" should not dictate how zooming in XD operates. Zooming in XD should either be linked to the operating system parameter and then switchable in-app or have its own setting in-app that does not read the setting in system preferences. The setting in System Preferences > Mouse > Point & Click > Scroll direction, makes sense when scrolling content vertically and does not relate intuitively to zooming content.