Multiple Layout Grids per Object / Artboard / Document
Right now the layout grid is very basic and solves just a very basic scenario. But with complex and large websites / apps that have nested column layouts it's to simple.
Taking Bootstrap 4 as a reference that allow you to create rows which also contain N amount of columns, it would be a massive help to be sure that this behaviour could be reproduced.
Deepak Madhana Raj K commented
Since there is grid(with gutter) feature within artboard, a static one. Is it possible to Integrate css fluid grid(like one present in bootstrap or integrae bootstrap into adobe xd) feature within artboard. So it acts responsive. Instead of writing it C++ or java code to make adobe xd to act responsive. Just a thought
Joachim Tillessen commented
I'm happy that Layout Grid is now available and I find this feature very useful. However I also find myself in situations, where I could use more guides, than layout grid alone. In InDesign I often display layout guides and grid together to design vertical rhythm and internal spaces right.
I tend to be a little compulsive when defining space in my designs and need to know that everything aligns according to a defined system.
It's not the same thing as Nils suggested, but it also has to do with the ability to combine multiple grid systems in one artboard.