Since some of you have mentioned wanting this for baseline grids, you might want to upvote this one (Baseline Grids) as well: https://adobexd.uservoice.com/forums/353007/suggestions/13030764
An error occurred while saving the commentTosin A. commented
You may wish to refer to Figma's implementation. Being able to create multiple layout guides/grids and have these visible at the same time is an important baseline for those of us who spend more time designing web UIs.
For me personally, the difficulty of having to repeatedly switch between these, and the absence of rulers and manual guides are all that is keeping me from using XD more regularly.