I work for a large ad agency. Currently we design in InDesign and export a PDF with margins to route through the agency and to and from our large, lucrative client. The margins are essential because we annotate the files. The PDF goes from department to department where stakeholders comment. The PDF is created by the art dept and lands back there and comments are addressed after it makes it's rounds.

We would need to be able to create margins on our PDF exports to hold the anotations in order to even consider using XD. I think that one tweak might do the trick.